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Die Martin-Luckner-Stiftung
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BioService Halle GmbH |
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An-Institut des Biozentrums der Martin-Luther-Universität Halle-Wittenberg BioService Halle GmbH, Weinbergweg 22, 06120 Halle |
分子診断部
ヒトインターロイキンの測定-1 遺伝子
The interleukin-1 (IL-1) family is composed of at least 6 proteins encoded by 3 genes. The IL-1A gene (the gene for the interleukin IL-1α), the IL-1B gene (the gene for the interleukin IL-1β) and the IL-1RN gene (the gene for the interleukin IL-1RA) are all located on the long arm of human chromosome 2. At the IL-1 locus several single-base polymorphisms are known. These gene variants either cause protein dimorphisms (e.g. IL-1A -889) and / or influence the level of IL-1 formation. IL-1B +3953, for instance, results in an increased formation of interleukin-1β. IL-1β is pro-inflammatory, a key regulator in the host responses to microbial infections and a major modulator of bone resorption.
Two of the polymorphisms in the IL-1 gene cluster (allele 2 of IL-1A -889 and IL-1B +3953) are correlated with severe adult periodontitis. All patients are at risk which carry at least in one of the both gene loci a copy of allel 2. We perform a test which allows determination of the presence of allel 2 in one or both loci, and basing on the results give an appraisal of the risk to develop periodontitis.
Are you interested in the proof of genetical disposition for increased formation of interleukin-1?
連絡は下記へお願いいたします:
| e-mail: | kuellertz@bioservice-halle.com |
| Phone: | ++49 - 345 - 55 59 638 |
| Fax: | ++49 - 345 - 55 59 669 |
| Mail address: | BioService Halle GmbH |
| Dr. Gabriele Küllertz | |
| Weinbergweg 22 | |
| 06120 Halle |
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